AXL

Description

Tyrosine-protein kinase receptor UFO (AXL). Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation.

Clinical trials

NCT03393936 - Renal Cancer

Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene AXL.

Target essentiality

Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present. The last three rows describe the position of potential epitopes, as well as phosphorylation and glycosylation sites.